abstract：:Neutrophil granulocytes (or polymorphonuclear cells, PMNs) have long been considered as crude killing machines, particularly trained to attack bacterial or fungal pathogens in wounds or infected tissues. That perspective has fundamentally changed over the last decades, as PMNs have been shown to exert a livery exchang...

journal_title：Neurochemistry international

authors： Strecker JK,Schmidt A,Schäbitz WR,Minnerup J

更新日期：2017-07-01 00:00:00

abstract：:The worldwide prevalence of stroke continues to rise despite recent successes in treating acute ischemic stroke. With limited patient eligibility and associated risk of tPA and mechanical thrombectomy, new preventive and therapeutic modalities are needed to stave the rising wave of stroke. Inflammation plays a key rol...

journal_title：Neurochemistry international

authors： Benedek G,Vandenbark AA,Alkayed NJ,Offner H

更新日期：2017-07-01 00:00:00

abstract：:In recent years there has been a great deal of research within the stem cell field which has led to the definition and classification of a range of stem cells from a plethora of tissues and organs. Stem cells, by classification, are considered to be pluri- or multipotent and have both self-renewal and multi-differenti...

journal_title：Neurochemistry international

authors： Lindsay SL,Barnett SC

更新日期：2017-06-01 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) are considered as a powerful tool for drug and chemical screening and development of new in vitro testing strategies in the field of toxicology, including neurotoxicity evaluation. These cells are able to expand and efficiently differentiate into different types of neurona...

journal_title：Neurochemistry international

authors： Zagoura D,Canovas-Jorda D,Pistollato F,Bremer-Hoffmann S,Bal-Price A

更新日期：2017-06-01 00:00:00

abstract：:Autism spectrum disorder is a neurodevelopmental disorder characterized by impaired social interaction, poor communication skills, and repetitive/restrictive behaviors. Elevated blood levels of pro-inflammatory cytokines have been reported in subjects with autism spectrum disorder. On the other hand, early childhood a...

journal_title：Neurochemistry international

authors： Makinodan M,Iwata K,Ikawa D,Yamashita Y,Yamamuro K,Toritsuka M,Kimoto S,Okumura K,Yamauchi T,Yoshino H,Tsujii M,Sugiyama T,Tsuchiya K,Mori N,Matsuzaki H,Kishimoto T

更新日期：2017-03-01 00:00:00

abstract：:The interaction of (±)-bupropion [(±)-BP] with the human (h) α4β2 nicotinic acetylcholine receptor (AChR) was compared to that for its photoreactive analog (±)-2-(N-tert-butylamino)-3'-iodo-4'-azidopropiophenone [(±)-SADU-3-72]. Ca2+ influx results indicated that (±)-SADU-3-72 and (±)-BP inhibit hα4β2 AChRs with pract...

journal_title：Neurochemistry international

authors： Arias HR,Feuerbach D,Ortells MO

更新日期：2016-11-01 00:00:00

abstract：:D1 and D2 receptors are key mediators of dopaminergic signaling in the brain, and since the manifestations of pathologies related to dopamine are different in female and male patients, it is important to analyze if there are sex-related differences in dopaminergic markers. To contribute to the knowledge in this regard...

journal_title：Neurochemistry international

authors： Orendain-Jaime EN,Ortega-Ibarra JM,López-Pérez SJ

更新日期：2016-11-01 00:00:00

abstract：:The increasing incidence of autism suggests a major environmental influence. Epidemiology has implicated many candidates and genetics many susceptibility genes. Gene/environment interactions in autism were analysed using 206 autism susceptibility genes (ASG's) from the Autworks database to interrogate ∼1 million chemi...

journal_title：Neurochemistry international

authors： Carter CJ,Blizard RA

更新日期：2016-10-27 00:00:00

abstract：:Agomelatine is a novel antidepressant with agonistic actions at melatonergic (MT1 and MT2 receptors) and antagonistic actions at 5HT-2C receptors. Venlafaxine, a serotonin norepinephrine reuptake inhibitor, is a widely prescribed drug in depression. The present study evaluated the low dose combinations of venlafaxine ...

journal_title：Neurochemistry international

authors： Thomas J,Khanam R,Vohora D

更新日期：2016-10-01 00:00:00

abstract：:Phosphine-borane complexes are novel cell-permeable drugs that protect neurons from axonal injury in vitro and in vivo. These drugs activate the extracellular signal-regulated kinases 1/2 (ERK1/2) cell survival pathway and are therefore neuroprotective, but do not scavenge superoxide. In order to understand the intera...

journal_title：Neurochemistry international

authors： Niemuth NJ,Thompson AF,Crowe ME,Lieven CJ,Levin LA

更新日期：2016-10-01 00:00:00

abstract：:Glycine can be substrate for two transporters: GlyT1, largely expressed by astrocytes but also by some non-glycinergic neurons, and GlyT2, most frequently present in glycine-storing nerve endings. In morphological studies, GlyT2 expression had been found to be restricted to caudal regions, being almost undetectable in...

journal_title：Neurochemistry international

authors： Romei C,Raiteri L

更新日期：2016-10-01 00:00:00

abstract：:Microglia, the primary resident immune cells of the central nervous system (CNS), responds rapidly to pathogens and injury by secreting immune mediators including nitric oxide (NO). The reaction of NO with the anti-oxidant glutathione forms S-nitrosoglutathione (GSNO), the major pool of biologic NO in the body. GSNO i...

journal_title：Neurochemistry international

authors： Rossi-George A,Guo CJ

更新日期：2016-10-01 00:00:00

abstract：:The multidrug transporter P-glycoprotein (P-gp) is expressed in the blood-brain barrier endothelium where it effluxes a range of drug substrates, preventing their accumulation within the brain. P-gp has been studied extensively for 40 years because of its crucial role in the absorption, distribution, metabolism and el...

journal_title：Neurochemistry international

authors： Subramanian N,Condic-Jurkic K,O'Mara ML

更新日期：2016-09-01 00:00:00

abstract：:Development of tissue structure and three-dimensional microenvironment is crucial for regeneration of axons in the peripheral nerve repair. In this study we aimed to evaluate the efficacy of nerve regeneration by using an acellular nerve allograft (ANA) injected with allogenic skin-derived precursor differentiated Sch...

journal_title：Neurochemistry international

authors： Wang H,Wu J,Zhang X,Ding L,Zeng Q

更新日期：2016-07-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress is linked to several neurological disorders, and neuronal injury cascades initiated by excessive ER stress are mediated, in part, via mitochondrial dysfunction. In the present study, we identified FAM3A as an important regulator of ER stress-induced cell death in neuronal HT22 cells. ...

journal_title：Neurochemistry international

authors： Song Q,Gou WL,Zhang R

更新日期：2016-03-01 00:00:00

abstract：:Melatonin has been proven to possess neuroprotection property against various neurological diseases by decreasing cerebral oxidative stress and inhibiting inflammatory process. However, whether administration of melatonin influences the autophagy pathway, which has recently been reported playing a pivotal role in trau...

journal_title：Neurochemistry international

authors： Ding K,Xu J,Wang H,Zhang L,Wu Y,Li T

更新日期：2015-12-01 00:00:00

abstract：:In the present study, we investigated the neuroprotective role of p38 inhibition on experimental stroke in rats. p38 inhibition treatment alleviated the brain infarction volume and neurological deficits following ischemia, promoted the activation of Extracellular signal-regulated kinases (ERK1/2), suppressed the activ...

journal_title：Neurochemistry international

authors： Zhang XM,Zhang L,Wang G,Niu W,He Z,Ding L,Jia J

更新日期：2015-11-01 00:00:00

abstract：:Açai (Euterpe oleracea Mart.), a highly consumed fruit in Amazon, is from a common palm with remarkable antioxidant properties. Because oxidative stress and seizures are intimately linked, this study investigated the potential neuroprotective and anticonvulsant effects of commercial clarified açai juice (EO). EO did n...

journal_title：Neurochemistry international

authors： Souza-Monteiro JR,Hamoy M,Santana-Coelho D,Arrifano GP,Paraense RS,Costa-Malaquias A,Mendonça JR,da Silva RF,Monteiro WS,Rogez H,de Oliveira DL,do Nascimento JL,Crespo-López ME

更新日期：2015-11-01 00:00:00

abstract：:Astrocytes, the most versatile cells of the central nervous system, play an important role in the regulation of neurotransmitter homeostasis, energy metabolism, antioxidant defenses and the anti-inflammatory response. Recently, our group characterized cortical astrocyte cultures from adult Wistar rats. In line with th...

journal_title：Neurochemistry international

authors： Souza DG,Bellaver B,Raupp GS,Souza DO,Quincozes-Santos A

更新日期：2015-11-01 00:00:00

abstract：:Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective treatment option for those affected by obsessive compulsive disorder, who do not respond to pharmacological treatment strategies. Yet, little is known about the mechanism by which DBS achieve its therapeutic effects. Previous studies have show...

journal_title：Neurochemistry international

authors： Varatharajan R,Joseph K,Neto SC,Hofmann UG,Moser A,Tronnier V

更新日期：2015-11-01 00:00:00

abstract：:Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have been proposed to be involved in the pyridoxal-5'-phosphate (PLP)-dependent biosynthesis of taurin...

journal_title：Neurochemistry international

authors： Winge I,Teigen K,Fossbakk A,Mahootchi E,Kleppe R,Sköldberg F,Kämpe O,Haavik J

更新日期：2015-11-01 00:00:00

abstract：:Vascular bed calcification is a common feature of ends stage renal disease that may lead to a complication in cardiovascular and cerebrovascular beds, which is a promoting cause of myocardial infarction, stroke, dementia and aneurysms. Sodium thiosulfate (STS) due to its multiple properties such as antioxidant and cal...

journal_title：Neurochemistry international

authors： Subhash N,Sriram R,Kurian GA

更新日期：2015-11-01 00:00:00

abstract：:The impact of dietary factors on brain health and vulnerability to disease is increasingly appreciated. The results of epidemiological studies, and intervention trials in animal models suggest that diets rich in phytochemicals can enhance neuroplasticity and resistance to neurodegeneration. Here we describe how intera...

journal_title：Neurochemistry international

authors： Murugaiyah V,Mattson MP

更新日期：2015-10-01 00:00:00

abstract：:Flavonoids that are found in nutraceuticals have many and varied effects on the activation of ionotropic receptors for GABA, the major inhibitory neurotransmitter in our brains. They can act as positive or negative modulators enhancing or reducing the effect of GABA. They can act as allosteric agonists. They can act t...

journal_title：Neurochemistry international

authors： Johnston GA

更新日期：2015-10-01 00:00:00

abstract：:Oxidative stress has for long been linked to the neuronal cell death in many neurodegenerative conditions. Conventional antioxidant therapies have been less effective in preventing neuronal damage caused by oxidative stress due to their inability to cross the blood brain barrier. Nanoparticle antioxidants constitute a...

journal_title：Neurochemistry international

authors： Sandhir R,Yadav A,Sunkaria A,Singhal N

更新日期：2015-10-01 00:00:00

abstract：:The GLS1 gene encodes a mitochondrial glutaminase that is highly expressed in brain, kidney, small intestine and many transformed cells. Recent studies have identified multiple lysine residues in glutaminase that are sites of N-acetylation. Interestingly, these sites are located within either a loop segment that regul...

journal_title：Neurochemistry international

authors： McDonald CJ,Acheff E,Kennedy R,Taylor L,Curthoys NP

更新日期：2015-09-01 00:00:00

abstract：:The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during n...

journal_title：Neurochemistry international

authors： Chia WJ,Tan FC,Ong WY,Dawe GS

更新日期：2015-08-01 00:00:00

abstract：:The influx of extracellular Zn(2+) into dentate granule cells is nonessential for dentate gyrus long-term potentiation (LTP) and the physiological significance of extracellular Zn(2+) dynamics is unknown in the dentate gyrus. Excess increase in extracellular Zn(2+) in the hippocampal CA1, which is induced with excitat...

journal_title：Neurochemistry international

authors： Suzuki M,Fujise Y,Tsuchiya Y,Tamano H,Takeda A

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Primary pathology underlying Parkinson's disease (PD) is the loss of dopaminergic neurons in the substantia nigra (SN). A variety of genetic and environmental factors underlie this loss of dopaminergic neurons. However, recent studies have highlighted the role of elevated oxidative stress and the pro-infla...

journal_title：Neurochemistry international

authors： Sharma N,Nehru B

更新日期：2015-08-01 00:00:00

abstract：:Glial scar is a major impediment to axonal regeneration in central nervous system (CNS) disorders. Overcoming this physical and biochemical barrier might be crucial for axonal regeneration and functional compensation during the progression of CNS disorders. The mammalian target of rapamycin (mTOR) is an evolutionarily...

journal_title：Neurochemistry international

authors： Li CY,Li X,Liu SF,Qu WS,Wang W,Tian DS

更新日期：2015-04-01 00:00:00

abstract：:The onset of attention-deficit-hyperactivity-disorder (ADHD) in childhood is characterized by developmentally inappropriate levels of hyperactivity, impulsivity and inattention. A chronic deficit of serotonin (5-HT) at the synapse may trigger symptoms of ADHD. This review focuses on neuro-anatomical, experimental and ...

journal_title：Neurochemistry international

authors： Banerjee E,Nandagopal K

更新日期：2015-03-01 00:00:00

abstract：:JM-20 (3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b][1,5]benzodiazepine) is a novel benzodiazepine dihydropyridine hybrid molecule, which has been shown to be a neuroprotective agent in brain disorders involving glutamate receptors. However, the effect of JM-20 on the functionality of the g...

journal_title：Neurochemistry international

authors： Nuñez-Figueredo Y,Pardo Andreu GL,Oliveira Loureiro S,Ganzella M,Ramírez-Sánchez J,Ochoa-Rodríguez E,Verdecia-Reyes Y,Delgado-Hernández R,Souza DO

更新日期：2015-02-01 00:00:00

abstract：:Gliomas are the most common and malignant primary brain tumours and are associated with a poor prognosis despite the availability of multiple therapeutic options. Quercetin, a traditional Chinese medicinal herb, is an important flavonoid and has anti-cancer activity. Here, we evaluated whether quercetin could inhibit ...

journal_title：Neurochemistry international

authors： Pan HC,Jiang Q,Yu Y,Mei JP,Cui YK,Zhao WJ

更新日期：2015-01-01 00:00:00

abstract：:Hyperlipidemia, low density lipoproteins (LDL) and their oxidized forms, and oxidative stress are suspected to be a key combination in the onset of AD and acetylcholinesterase (AChE) plays a part in this pathology. The present study aimed to link these parameters using differentiated SH-SY5Y human neuroblastoma cells ...

journal_title：Neurochemistry international

authors： Yamchuen P,Aimjongjun S,Limpeanchob N

更新日期：2014-12-01 00:00:00

abstract：:RBFox proteins are well-known alternative splicing regulators. We have shown previously that during neuronal differentiation of P19 cells induced by all-trans retinoic acid and cell aggregation, RBFox1 shows markedly increased temporal expression. To find its key splicing regulation, we examined the effect of RBFox1 o...

journal_title：Neurochemistry international

authors： Alam S,Suzuki H,Tsukahara T

更新日期：2014-12-01 00:00:00

abstract：:This study aimed to elucidate locomotor activity changes in 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) and investigate the possible beneficial effects of melatonin on altered levels of locomotor activity, cyclooxygenase (COX), prostaglandin E2 (PGE2), nuclear factor kappa-B (NF-κB), nitrate/nitrite an...

journal_title：Neurochemistry international

authors： Yildirim FB,Ozsoy O,Tanriover G,Kaya Y,Ogut E,Gemici B,Dilmac S,Ozkan A,Agar A,Aslan M

更新日期：2014-12-01 00:00:00

abstract：:MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their...

journal_title：Neurochemistry international

authors： Brower JV,Clark PA,Lyon W,Kuo JS

更新日期：2014-11-01 00:00:00

abstract：:Chemokine-like factor 1 (CKLF1) is a novel C-C chemokine, and plays important roles in immune response and brain development. In previous study, we have found that the expression of CKLF1 increased after focal cerebral ischemia and inhibition of CKLF1 using antagonist C19 peptide protected against cerebral ischemia. H...

journal_title：Neurochemistry international

authors： Kong LL,Wang ZY,Hu JF,Yuan YH,Han N,Li H,Chen NH

更新日期：2014-10-01 00:00:00

abstract：:Intoxication with inorganic arsenicals leads to neuropathies and impaired cognitive functions. However, little is known so far on the cellular targets that are involved in the adverse effects of arsenite to brain cells. To test whether arsenite may affect neural glucose and glutathione (GSH) metabolism, primary astroc...

journal_title：Neurochemistry international

authors： Tadepalle N,Koehler Y,Brandmann M,Meyer N,Dringen R

更新日期：2014-10-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor is a subtype of ionotropic glutamate receptor that is involved in synaptic mechanisms of learning and memory, and mediates excitotoxic neuronal injury. In this study, we tested the hypothesis that NMDA receptor subunit gene expression is altered in cortex and hippocampus of OKA...

journal_title：Neurochemistry international

authors： Kamat PK,Rai S,Swarnkar S,Shukla R,Nath C

更新日期：2014-10-01 00:00:00